Postdoctoral Fellows, Dudley Lab

The Dudley Laboratory at the Pacific Northwest Research Institute (PNRI) in Seattle, WA seeks two creative and motivated Postdoctoral Fellows who are passionate about using genetics and high throughput technologies to improve the diagnosis and treatment of rare genetic diseases. 

Research in the Dudley Lab focuses on deciphering the principles that govern the genetic basis of inheritance. We have used creative, multidisciplinary, and collaborative approaches to decipher fundamental principles of genetics, explore global microbial population structures, and interrogate cellular processes associated with fungal pathogenesis. We have been particularly active in developing methods that enable large-scale genetic analysis, including high throughput approaches for generating recombinant yeast strains, molecular barcoding strategies for deconvolving strain relationships, and automated image analysis software for measuring quantitative traits. Recently our lab has also focused on developing yeast models of human disease genes and using them to test the functional impact of genetic variation seen in the human population. Our publications can be found at:

Successful candidates will lead projects focused on measuring the functional impact of human genetic variation. The highly collaborative, interdisciplinary nature of our laboratory provides a strong training environment in the areas of human genetics and genomics, as well as the opportunity to collaborate with world experts in the field of rare diseases. The Dudley Lab and the broader PNRI community actively strive to increase diversity in STEM, translate our discoveries in ways that benefit society, and train the next generation of scientists. Successful candidates will have opportunities to explore the clinical, translational, and commercial applications of their work and to mentor students

What you will do:

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

  • Design, develop, implement, and execute scientific research under supervision of Principal Investigator.
  • Perform periodical/literature searches in preparation for study design.
  • Maintain substantial knowledge of current scientific and theories.
  • Prepare laboratory equipment and resources.
  • Conduct research, monitor experiments, make observations, and perform hands on observations and activities.
  • Participate in analysis and interpretation of study data.
  • Contribute to scientific literature, grant writing, and conferences in conjunction with Principal Investigator.
  • May develop and implement methodologies, instrumentation, and procedures.
  • May mentor undergraduate and graduate students.

What you bring:

To perform this job successfully, an individual should be able to demonstrate the requirements listed below which are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

  • Doctoral degree (PhD, MD, or equivalent) required.
  • Prior experience in a research environment required.
  • Demonstrated knowledge and expertise in genetics and molecular biology required.
  • Demonstrable experience with Saccharomyces cerevisiae or other yeast preferred.
  • Verifiable experience with high throughput genetic screens, robotics, next-generation sequencing, synthetic biology or human genetics are a plus.
  • Demonstrated motivation and ability for applying new technologies to exciting research questions.
  • Demonstrable written and verbal communication skills and the proven ability to thrive in a team environment and work collaboratively as well as independently.
  • Track record of publication in peer-reviewed journals.

PNRI is committed to creating a diverse environment and all qualified candidates are encouraged to apply.

How to apply:

The annual base salary for this position is from $69,264.00 to $78,295.00 and the wage offered will be based on experience, qualifications and the NRSA stipend level.

PNRI requires vaccination for COVID 19 as a condition of employment. Please see for more information.

To apply, please complete and submit your application today.

About PNRI

PNRI is an independent, nonprofit, biomedical research institute with a distinguished history of contributing scientific advances to improve health. We believe genetic research holds untapped potential to improve human health. PNRI pursues an unanswered question in the field of genetics: what keeps people healthy in the face of genetic and environmental risk?  At PNRI, our culture encourages originality, risk-taking, and interdisciplinary collaboration. 

PNRI is an equal opportunity employer.  PNRI does not, and will not, discriminate against any applicant or employee on the basis of race, creed, ancestry, color, religion, sex, gender, gender identity/expression, sexual orientation, national origin, citizenship status, mental or physical disability, age, genetic information, veteran status, marital or family status, family or medical care leave, pregnancy or related condition (including childbirth and/or nursing), political affiliation or any other characteristic protected by state or federal law or local ordinance.  We believe diversity, equity, inclusion, and belonging is not only good business, it’s the right thing to do.