Recent Blog Posts
-
Two Wrongs Make a Right: How Two Damaging Variants Can Restore Health
A groundbreaking PNRI study overturns long-held genetic assumptions, revealing interactions that could enable more accurate, personalized medicine for rare disorders.
-
OTC Gene Variants Explained: From Testing to Care
PNRI researchers help clarify how OTC gene variants influence health—turning genetic findings into guidance for care, prevention, and early intervention.
-
Rally for Research, Families, and Hope at “Hope on the Court”
Join PNRI at Hope on the Court—a Seattle pickleball tournament benefiting families affected by Arginase 1 Deficiency. Rally for research, families, and hope! 💙 hopeonthecourt.com
-
Pacific Northwest Research Institute Publishes Key Advances in Rare and Genetic Disease Research Amid National Funding Uncertainty
Despite a challenging year for research funding, PNRI scientists moved discovery forward with 21 studies in the past year, shedding light on genetic disorders, cancer biology, and hidden patterns in the human genome – breakthroughs that demonstrate the impact of continued investment in biomedical research.
-
Pacific Northwest Research Institute Announces Listing of Building at 720 Broadway in Seattle
PNRI lists its 45,000-sq-ft headquarters at 720 Broadway in Seattle for sale to position the institute for future research sustainability and growth.
-
A Summer of Discovery: PNRI’s 2025 SURI Interns Take the Stage
From cancer in clams to rare disease genomics, PNRI’s 2025 SURI interns spent the summer tackling big questions through hands-on research.
Recent Media Coverage
ASL/ASA yeast genetics study yields severity predictions, groundbreaking insights on genetic variant interactions
NUCDF highlights a groundbreaking ASL/ASA yeast genetics study from PNRI’s Dudley Lab — revealing new predictions of variant severity and surprising genetic interactions that could reshape how we understand inherited disorders.
Two Harmful Genetic Variants Can Restore Gene Function
Technology Networks highlighted PNRI’s latest PNAS paper from the Dudley Lab: after testing thousands of variant combinations, researchers found that over 60% of “damaging” pairs restored enzyme activity toward healthy levels.
Two Harmful Genetic Variants Can Restore Gene Function
More coverage of the Dudley Lab’s groundbreaking PNAS study showing that two individually harmful variants can sometimes “rescue” protein function—challenging a core assumption in human genetics.
Two Wrongs Make a Right: How Two Damaging Variants Can Restore Health
Science in Seattle spotlighted a new PNAS study from PNRI’s Dudley Lab showing that two individually harmful variants can sometimes “rescue” protein function—challenging a core assumption in human genetics.
OTC Gene Variants Explained: From Testing to Care
Science in Seattle shares how the Dudley Lab is making sense of changes in the OTC gene, using yeast to test how those changes work and helping families better understand and manage OTC deficiency.
Scientist Who Was Offline ‘Living His Best Life’ Stunned by Nobel Prize Win
WIRED highlights the 2025 Nobel Prize in Physiology or Medicine awarded to Fred Ramsdell, Mary Brunkow, and Shimon Sakaguchi for discoveries in immune tolerance—research originally guided by former PNRI scientist Dr. David Galas.
Media Requests
Please visit our Media Inquiries page to contact us with your request.