Aimée M. Dudley, PhD
Senior Investigator and Interim Chief Scientific Officer
Lab Focus
Genetics
Technology Development
Rare Disease Research
Overview
PNRI’s Dudley Lab explores how naturally occurring genetic variation leads to the stunning array of phenotypic diversity on the planet. This team uses genetics, genomics, leading edge technologies, and the awesome power of yeast genetics to address a wide array of biological problems.
The Dudley Lab’s creative, multidisciplinary, and collaborative approaches have allowed them to decipher fundamental principles in genetics, explore global microbial population structures, and interrogate cellular processes associated with fungal pathogenesis. The lab’s current research interests include improving methods for genetic mapping, circumventing antifungal drug resistance, using high throughput assays to assess the functional impact of human genetic variation, and advancing the diagnosis and treatment of rare diseases.
“Many of our lab’s results will be used by patients, their families, and physicians to help make important life decisions. We take that responsibility very seriously.”
Aimée M. Dudley, PhD
Senior Investigator and Interim Chief Scientific Officer
Lab Members
Gareth Cromie, PhD
Senior Computational Biologist
Russell Lo
Staff Scientist
Anubhav Nahar, PhD
Postdoctoral Fellow
Michelle Tang, PhD
Staff Scientist
Martin Timour
Senior Research Project Specialist
Biography
Aimée Dudley, PhD
Aimée Dudley, PhD, is a Senior Investigator and Interim Chief Scientific Officer at PNRI. She earned her BS in biochemistry and molecular biology from the University of Massachusetts at Amherst and her PhD in genetics from Harvard Medical School. Dr. Dudley was an Alexander Hollaender Distinguished Postdoctoral Fellow in Dr. George Church’s laboratory at Harvard Medical School. In addition to her roles at PNRI, Dr. Dudley is a scientific advisor to FenoLogica Biosciences, a scientific instrumentation company founded on technology developed in her lab. She serves as an Editor-in-Chief at PLoS Genetics. Dr. Dudley also co-chairs the Washington Research Foundation’s Postdoctoral Fellowship Selection Committee. In her previous role as PNRI’s Director of Educational Outreach, she partnered with community groups to bring high school and undergraduate students from underrepresented communities to PNRI to explore science as a career. She also mentors graduate students through her affiliate appointment in the University of Washington’s Department of Genome Sciences, and as a faculty member in the Molecular Engineering Graduate Program and the Molecular and Cellular Biology Graduate Program.
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Research Projects
Dudley
Improving the diagnosis and treatment of inherited metabolic diseases
Inherited metabolic diseases are potentially life-threatening disorders that often appear in newborns or young children. Many have effective treatments, but reducing morbidity and mortality depends on timely diagnosis. The limitation of genome sequencing-based diagnostics is no longer their cost or turnaround time, but the fact that the consequences of most genetic variants are unknown.
Publications
Dudley Lab in the News
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