Recent Blog Posts
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Two Wrongs Make a Right: How Two Damaging Variants Can Restore Health
A groundbreaking PNRI study overturns long-held genetic assumptions, revealing interactions that could enable more accurate, personalized medicine for rare disorders.
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OTC Gene Variants Explained: From Testing to Care
PNRI researchers help clarify how OTC gene variants influence health—turning genetic findings into guidance for care, prevention, and early intervention.
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Rally for Research, Families, and Hope at “Hope on the Court”
Join PNRI at Hope on the Court—a Seattle pickleball tournament benefiting families affected by Arginase 1 Deficiency. Rally for research, families, and hope! 💙 hopeonthecourt.com
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Pacific Northwest Research Institute Publishes Key Advances in Rare and Genetic Disease Research Amid National Funding Uncertainty
Despite a challenging year for research funding, PNRI scientists moved discovery forward with 21 studies in the past year, shedding light on genetic disorders, cancer biology, and hidden patterns in the human genome – breakthroughs that demonstrate the impact of continued investment in biomedical research.
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Pacific Northwest Research Institute Announces Listing of Building at 720 Broadway in Seattle
PNRI lists its 45,000-sq-ft headquarters at 720 Broadway in Seattle for sale to position the institute for future research sustainability and growth.
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A Summer of Discovery: PNRI’s 2025 SURI Interns Take the Stage
From cancer in clams to rare disease genomics, PNRI’s 2025 SURI interns spent the summer tackling big questions through hands-on research.
Recent Media Coverage
Two Harmful Variants Can Restore Protein Function
The Scientist highlights a groundbreaking study from the Dudley Lab showing that two harmful genetic variants can sometimes restore protein function—challenging long-held assumptions in genetics.
Scientists Discovered That Two Genetic ‘Wrongs’ Could Make a Genetic ‘Right’
Popular Mechanics covers a Dudley Lab discovery revealing that, in certain cases, two disease-linked variants can offset each other and restore protein function—reshaping how scientists think about genetic risk.
ASL/ASA yeast genetics study yields severity predictions, groundbreaking insights on genetic variant interactions
NUCDF highlights a groundbreaking ASL/ASA yeast genetics study from PNRI’s Dudley Lab — revealing new predictions of variant severity and surprising genetic interactions that could reshape how we understand inherited disorders.
Two Harmful Genetic Variants Can Restore Gene Function
Technology Networks highlighted PNRI’s latest PNAS paper from the Dudley Lab: after testing thousands of variant combinations, researchers found that over 60% of “damaging” pairs restored enzyme activity toward healthy levels.
Two Harmful Genetic Variants Can Restore Gene Function
More coverage of the Dudley Lab’s groundbreaking PNAS study showing that two individually harmful variants can sometimes “rescue” protein function—challenging a core assumption in human genetics.
Two Wrongs Make a Right: How Two Damaging Variants Can Restore Health
Science in Seattle spotlighted a new PNAS study from PNRI’s Dudley Lab showing that two individually harmful variants can sometimes “rescue” protein function—challenging a core assumption in human genetics.
Media Requests
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