Contagious Cancer Poses Possible Threat to Salish Sea Clams
What if cancer, already one of the deadliest diseases known to the animal kingdom, suddenly became contagious? Among certain species it has. Now, it’s happening in the Salish Sea.
Metzger Lab
Two Harmful Variants Can Restore Protein Function
The Scientist highlights a groundbreaking study from the Dudley Lab showing that two harmful genetic variants can sometimes restore protein function—challenging long-held assumptions in genetics.
Dudley Lab
Scientists Discovered That Two Genetic ‘Wrongs’ Could Make a Genetic ‘Right’
Popular Mechanics covers a Dudley Lab discovery revealing that, in certain cases, two disease-linked variants can offset each other and restore protein function—reshaping how scientists think about genetic risk.
Dudley Lab
ASL/ASA yeast genetics study yields severity predictions, groundbreaking insights on genetic variant interactions
NUCDF highlights a groundbreaking ASL/ASA yeast genetics study from PNRI’s Dudley Lab — revealing new predictions of variant severity and surprising genetic interactions that could reshape how we understand inherited disorders.
Dudley Lab
Two Harmful Genetic Variants Can Restore Gene Function
Technology Networks highlighted PNRI’s latest PNAS paper from the Dudley Lab: after testing thousands of variant combinations, researchers found that over 60% of “damaging” pairs restored enzyme activity toward healthy levels.
Dudley Lab
Two Harmful Genetic Variants Can Restore Gene Function
More coverage of the Dudley Lab’s groundbreaking PNAS study showing that two individually harmful variants can sometimes “rescue” protein function—challenging a core assumption in human genetics.
Dudley Lab
Two Wrongs Make a Right: How Two Damaging Variants Can Restore Health
Science in Seattle spotlighted a new PNAS study from PNRI’s Dudley Lab showing that two individually harmful variants can sometimes “rescue” protein function—challenging a core assumption in human genetics.
Dudley Lab
OTC Gene Variants Explained: From Testing to Care
Science in Seattle shares how the Dudley Lab is making sense of changes in the OTC gene, using yeast to test how those changes work and helping families better understand and manage OTC deficiency.
Scientist Who Was Offline ‘Living His Best Life’ Stunned by Nobel Prize Win
WIRED highlights the 2025 Nobel Prize in Physiology or Medicine awarded to Fred Ramsdell, Mary Brunkow, and Shimon Sakaguchi for discoveries in immune tolerance—research originally guided by former PNRI scientist Dr. David Galas.
Seattle research institute puts longtime headquarters on the market
Puget Sound Business Journal reports on PNRI’s decision to list our longtime Seattle headquarters for $9.5 million while exploring future space options.