ASL/ASA yeast genetics study yields severity predictions, groundbreaking insights on genetic variant interactions
NUCDF highlights a groundbreaking ASL/ASA yeast genetics study from PNRI’s Dudley Lab — revealing new predictions of variant severity and surprising genetic interactions that could reshape how we understand inherited disorders.
Dudley Lab
Two Harmful Genetic Variants Can Restore Gene Function
Technology Networks highlighted PNRI’s latest PNAS paper from the Dudley Lab: after testing thousands of variant combinations, researchers found that over 60% of “damaging” pairs restored enzyme activity toward healthy levels.
Dudley Lab
Two Harmful Genetic Variants Can Restore Gene Function
More coverage of the Dudley Lab’s groundbreaking PNAS study showing that two individually harmful variants can sometimes “rescue” protein function—challenging a core assumption in human genetics.
Dudley Lab
Two Wrongs Make a Right: How Two Damaging Variants Can Restore Health
Science in Seattle spotlighted a new PNAS study from PNRI’s Dudley Lab showing that two individually harmful variants can sometimes “rescue” protein function—challenging a core assumption in human genetics.
Dudley Lab
OTC Gene Variants Explained: From Testing to Care
Science in Seattle shares how the Dudley Lab is making sense of changes in the OTC gene, using yeast to test how those changes work and helping families better understand and manage OTC deficiency.
Scientist Who Was Offline ‘Living His Best Life’ Stunned by Nobel Prize Win
WIRED highlights the 2025 Nobel Prize in Physiology or Medicine awarded to Fred Ramsdell, Mary Brunkow, and Shimon Sakaguchi for discoveries in immune tolerance—research originally guided by former PNRI scientist Dr. David Galas.
Seattle research institute puts longtime headquarters on the market
Puget Sound Business Journal reports on PNRI’s decision to list our longtime Seattle headquarters for $9.5 million while exploring future space options.
A Summer of Discovery: PNRI’s 2025 SURI Interns Take the Stage
Science in Seattle: PNRI’s 2025 SURI interns take the stage—eight projects, new skills, and big discoveries.
PNRI Announces Leadership Transition and Welcomes New COO
Science in Seattle spotlights PNRI’s leadership transition—celebrating CEO Jack Faris, PhD’s service and welcoming Mark Rieder, PhD as our new COO.
Seattle Times Op-Ed: Federal research funding cuts interrupt vital, lifesaving work
The Seattle Times published an op-ed by PNRI CEO, Jack Faris, PhD, and Interim Chief Scientific Officer & Senior Investigator, Aimée Dudley, PhD, highlighting the real-world consequences of when federal research funding is disrupted—not just for scientists, but for the millions of people waiting for a diagnosis, treatment, or cure.
PNRI