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October 9, 2023 | PLoS Genetics
Dudley Lab

Constructing and interpreting a large-scale variant effect map for an ultrarare disease gene: Comprehensive prediction of the functional impact of PSAT1 genotypes

Michael J. Xie, Gareth A. Cromie, Katherine Owens, Martin S. Timour, Michelle Tang, J. Nathan Kutz, Ayman W. El-Hattab, Richard N. McLaughlin Jr., Aimée M. Dudley

May 4, 2023 | AJHG
Dudley Lab

The functional impact of 1,570 SNP-accessible missense variants in human OTC

Russell S. Lo, Gareth A. Cromie, Michelle Tang, Kevin Teng, Katherine Owens, Amy Sirr, J. Nathan Kutz, Hiroki Morizono, Ljubica Caldovic, Nicholas Ah Mew, Andrew Gropman, Aimée M. Dudley

June 15, 2022 | Yeast
Dudley Lab

A method for quantifying sporulation efficiency and isolating meiotic progeny in non‐GMO strains of Saccharomyces cerevisiae

Amy Sirr, Martin S Timour, Gareth A Cromie, Michelle Tang, Aimée M Dudley

May 17, 2022 | Scientific Data
Dudley Lab

Quantifying yeast colony morphologies with feature engineering from time-lapse photography

Andy Goldschmidt, James Kunert-Graf, Adrian C Scott, Zhihao Tan, Aimée M Dudley, J Nathan Kutz

December 31, 2020 | Frontiers in Genetics
Dudley Lab

Exploiting the autozygome to support previously published mendelian gene-disease associations: An update

Sateesh Maddirevula, Hanan E Shamseldin, Amy Sirr, Lama AlAbdi, Russell S Lo, Nour Ewida, Mashael Al-Qahtani, Mais Hashem, Firdous Abdulwahab, Omar Aboyousef, Namik Kaya, Dorota Monies, May H Salem, Naffaa Al Harbi, Hesham M Aldhalaan, Hamad Alzaidan, Hadeel M Almanea, Abrar K Alsalamah, Fuad Al Mutairi, Samira Ismail, Ghada MH Abdel-Salam, Amal Alhashem, Ali Asery, Eissa Faqeih, Amal AlQassmi, Waleed Al-Hamoudi, Talal Algoufi, Mohammad Shagrani, Aimée M Dudley, Fowzan S Alkuraya

July 1, 2020 | Journal of Inherited Metabolic Disease
Dudley Lab

A yeast‐based complementation assay elucidates the functional impact of 200 missense variants in human PSAT1

Amy Sirr, Russell S Lo, Gareth A Cromie, Adrian C Scott, Julee Ashmead, Mirutse Heyesus, Aimée M Dudley

December 19, 2019 | BMC Molecular and Cell Biology
Dudley Lab

Data-driven multiscale modeling reveals the role of metabolic coupling for the spatio-temporal growth dynamics of yeast colonies

Jukka Intosalmi, Adrian C Scott, Michelle Hays, Nicholas Flann, Olli Yli-Harja, Harri Lähdesmäki, Aimée M Dudley, Alexander Skupin

July 1, 2019 | G3: Genes, Genomes, Genetics
Dudley Lab

Computational Inference Software for Tetrad Assembly from Randomly Arrayed Yeast Colonies

Nikita A Sakhanenko, Gareth A Cromie, Aimée M Dudley, David J Galas

May 15, 2019 | PLOS Genetics
Dudley Lab

Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype

Anja Forche, Norma V Solis, Marc Swidergall, Robert Thomas, Alison Guyer, Annette Beach, Gareth A Cromie, Giang T Le, Emily Lowell, Norman Pavelka, Judith Berman, Aimeé M Dudley, Anna Selmecki, Scott G Filler

March 5, 2019 | PLoS Biol.
Dudley Lab

A polyploid admixed origin of beer yeasts derived from European and Asian wine populations

Justin C Fay, Ping Liu, Giang T Ong, Maitreya J Dunham, Gareth A Cromie, Eric W Jeffery, Catherine L Ludlow, Aimée M Dudley