A Dudley Lab Study That’s Rewriting Genetic Assumptions
Dudley Lab’s PNAS study is rewriting genetic assumptions—showing some harmful variants can restore function together. See the coverage and read the study.
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Two Wrongs Make a Right: How Two Damaging Variants Can Restore Health
A groundbreaking PNRI study overturns long-held genetic assumptions, revealing interactions that could enable more accurate, personalized medicine for rare disorders.
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OTC Gene Variants Explained: From Testing to Care
PNRI researchers help clarify how OTC gene variants influence health—turning genetic findings into guidance for care, prevention, and early intervention.
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Rally for Research, Families, and Hope at “Hope on the Court”
Join PNRI at Hope on the Court—a Seattle pickleball tournament benefiting families affected by Arginase 1 Deficiency. Rally for research, families, and hope! 💙 hopeonthecourt.com
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Pacific Northwest Research Institute Publishes Key Advances in Rare and Genetic Disease Research Amid National Funding Uncertainty
Despite a challenging year for research funding, PNRI scientists moved discovery forward with 21 studies in the past year, shedding light on genetic disorders, cancer biology, and hidden patterns in the human genome – breakthroughs that demonstrate the impact of continued investment in biomedical research.
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Pacific Northwest Research Institute Announces Listing of Building at 720 Broadway in Seattle
PNRI lists its 45,000-sq-ft headquarters at 720 Broadway in Seattle for sale to position the institute for future research sustainability and growth.
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A Summer of Discovery: PNRI’s 2025 SURI Interns Take the Stage
From cancer in clams to rare disease genomics, PNRI’s 2025 SURI interns spent the summer tackling big questions through hands-on research.
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Carvalho Lab Shares New Insights Into Rare Diseases, Inversions, and Complex Genomic Rearrangements
New research from PNRI’s Carvalho Lab reveals how complex genomic rearrangements like inversions may help solve rare disease cases that defy standard diagnosis.
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PNRI Announces Leadership Transition and Welcomes New COO
PNRI welcomes new COO Mark Rieder, PhD, and honors retiring CEO Jack Faris, PhD, marking a new chapter in advancing genetic research.
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Rare Disease, Real Progress: Season 2 of PNRI’s Podcast Is Here
Listen now to PNRI Science: Rare Disease, Real Progress – our latest podcast series featuring conversations from our 2025 Rare Disease Day Symposium with scientists, advocates, and industry leaders accelerating rare disease research.